Unlocking Success with Aurlide’s Cutting-Edge Solutions
Discovery of your hits
- At Aurlide, we redefine the efficiency of hit identification with our groundbreaking vHTS technology. Experience an exceptionally high hit and success rate in identifying your first hits. Our track record speaks for itself, with our team having already identified 1st-in-class protein-protein interaction modulators for nearly 20 target proteins and over 3000 active ligands for more than 30 classical target proteins.
Enlargement of hit space
- Take your research to new heights with our revolutionary hit space enlargement capabilities. Aurlide’s in-house technology allows us to seamlessly integrate your existing hits and inactive molecules into our vHTS model. This results in a vast array of fresh structural solutions and an expanded range of compounds, all designed to propel your project forward. At the end of the hit space enlargement, you have practically at the crossroads to select your lead and its backup molecules. Aurlide’s approach not only saves time and money but also accelerates success in the clinical phases.
Streamlined Hit-to-Lead Optimization
- With Aurlide’s cutting-edge technology for hit space expansion, hit-to-lead optimization becomes a breeze. Our agile approach enables swift optimization of hit molecules, including core hopping, to create novel high-affinity ligands. This not only accelerates your journey to clinical phases but also ensures significant savings in both time and resources.
Collaborate for Success!
Just humans? How about animal tests?
- Simultaneous optimization of binding into proteins from human and other wished species. By using Aurlide’s structural bioinformatics platform, it is possible to identify suitable animals to understand the effect of molecules in vivo. Furthermore, at Aurlide, we can optimize the molecules to bind to proteins in the intended target species and species used in animal tests. This way, we can significantly lower the risk of failures in the pre-clinical and clinical phases.
Pharmacokinetics
In the intricate world of drug discovery and development, understanding the pharmacokinetics of your molecules is paramount. At Aurlide, we not only recognize this significance but have harnessed it to create a suite of cutting-edge tools that set us apart.
Precision in Prediction and Measurement
We specialize in predictive and measurement tools tailored to decipher the pharmacokinetic properties of your compounds. For instance, solving the macrocycle permeability is a challenge we’ve conquered. Leveraging machine learning, we’ve crafted a state-of-the-art model that accurately forecasts passive permeation of amino acid -based macrocycles.
Pioneering Metabolic Insights
We’re developing highly efficient tools and predictions to predict te site of metabolism and the metabolites. Our arsenal also includes a rich array of pro-fluorescent tool compounds, designed to make metabolic studies cost-effective.
Aurlide – Where pharmacokinetics in an essential part of the molecular discovery
Software and Workflow Development
Obviously, as the currently available software tools have their limitations, we develop tools for various problems, which include e.g. virtual screening, data handling and analysis. Furthermore, we develop workflows that identify active ligands with higher precision than previously published ones – still keeping in mind that time is a precious variable.